Abstract：Nuclear receptor co-activator 1 gene (NCOA1) is one of the members of steroid hormone receptor which is essential for growth and differentiation of ovarian follicles. Single nucleotide polymorphisms (SNPs) were detected by PCR-SSCP, and two SNPs was found at exon 3 and 12. Rea1-time quantitative PCR was used for identification of expression changes of NCOA1 gene at exon 3 and 12. Results indicated that NCOA1 gene expression was increased along with growth as undulatory property and few before 14 weeks. NCOA1 gene expression was rapidly increased along with sex maturation, and high expression was found at 28 weeks then decreased. NCOA1 expression level of female line was easier than that of male line and significantly higher mRNA expression after 14 weeks (P<0.05). The advantage genotyps of AA and CC which significantly influenced the egg performance of individual expression, was significantly higher than that of the other genotype within the same site after 16 weeks (P<0.05). NCOA1 genes may play an important role in the process of sexual maturation and egg production performance.
