Abstract：In the nucleus of mammals, chromatins are folded into various three-dimensional structural units, such as chromosome territories, chromatin compartments, topologically associating domains, and chromatin loops, etc. These structural units play key roles in the regulation of gene expression, cell differentiation and disease development. Previous studies suggested that these structural units represented three dimensional conformations of chromatin at different levels, and distributed hierarchically in mammalian cell nuclei. In recent years, with the rapid development of new technologies of chromatin conformation capture, it has been found that these structural units may not be a simple hierarchical architecture in the nucleus. In this review, we summarize the recently developed technologies of chromatin conformation capture,detailly describe the features and functions of different three-dimensional structural units of chromatin folding.Particularly, we focused on the interrelation among different chromatin structural units. This review provides a valuable reference for subsequent studies.
罗扶农, 何梦楠, 唐茜子, 李严, 李明洲, 金龙. 哺乳动物染色质三维结构单元的特征及其相互关系[J]. 农业生物技术学报, 2019, 27(8): 1485-1497.
LUO Fu-Nong, HE Meng-Nan, TANG Qian-Zi, LI Yan, LI Ming-Zhou, JIN Long. The Characteristics and Interrelation of Three-dimensional Structural Units of Chromatin in Mammals. 农业生物技术学报, 2019, 27(8): 1485-1497.
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