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2025年8月11日 星期一
农业生物技术学报  2019, Vol. 27 Issue (2): 348-360    DOI: 10.3969/j.issn.1674-7968.2019.02.018
  研究评述与展望 本期目录 | 过刊浏览 | 高级检索 |
植物Sec14-like磷脂酰肌醇转运蛋白:变化的结构和多样的功能
毛花英, 苏亚春, 阙友雄*
福建农林大学 农业部福建甘蔗生物学与遗传育种重点实验室/福建农林大学 教育部作物遗传育种与综合利用重点实验室,福州 350002
Plant Sec14-like Phosphatidylinositol Transfer Proteins: Diverse Structures and Multi-Functions
MAO Hua-Ying, SU Ya-Chun, QUE You-Xiong*
Key Laboratory of Sugarcane Biology and Genetic Breeding, Ministry of Agriculture, Fujian Agriculture and Forestry University / Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China
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摘要 Sec14p是最早在酿酒酵母(Saccharomyces cerevisiae)中发现的具有转运磷脂酰肌醇(phosphatidylinositol, PI)和磷脂酰胆碱(phosphatidylcholine, PC)功能的一类磷脂酰肌醇转运蛋白(phosphatidylinositol transfer proteins, PITPs),广泛存在于真核生物中。植物Sec14-like磷脂酰肌醇转运蛋白与酵母Sec14p存在较高的序列同源性。近年来,随着分子生物学和脂质基因组学的发展,越来越多的植物PITPs被挖掘。该类蛋白的结构由最初的Sec14p结构域进化到与膜定位Nlj16结构域、囊泡运输相关GOLD (Golgi dynamics)结构域结合,致使该类蛋白在植物体内行使的功能分化导致多样性,包括渗透调节、细胞极性生长、根瘤发育、蛋白运输、植物免疫调节和病毒相互作用等。本文主要综述了目前发现的三类植物Sec14-like磷脂酰肌醇转运蛋白Sec14-only proteins, Sec14-nodulin proteins和Sec14-GOLD proteins在结构和功能上的区别与联系,探讨其生物学功能多样性。
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毛花英
苏亚春
阙友雄
关键词 Sec14-like磷脂酰肌醇转运蛋白Sec14-nodulinSec14-GOLD结构多样的功能    
Abstract:Sec14p, one of the phosphatidylinositol transfer proteins (PITPs), is originally found in Saccharomyces cerevisiae that has the functions of transporting phosphatidylinositol (phosphatidylinositol, PI) and phosphatidylcholine (phosphatidylcholine, PC) and is widely present in eukaryotes. Plant Sec14-like phosphatidylinositol transfer protein has high sequence homology with yeast Sec14p. In recent years, with the development of molecular biology and lipid genomics, more and more plant phosphatidylinositol transfer proteins have been excavated. In plants, the structure of those proteins has evolved from the original Sec14p domain to integrate with the membrane-localized Nlj16 domain and the vesicle transport Golgi dynamics (GOLD) domain, resulting in multi-functions, such as osmotic regulation, cell polarity growth, nodule development, protein transport, plant immune regulation and virus interactions. This paper reviews the differences and associations of structures and functions among Sec14-only proteins, Sec14-nodulin proteins and Sec14-GOLD proteins in plants, and highlights their multiple biological functions.
Key wordsSec14-like phosphatidylinositol transfer proteins    Sec14-nodulin    Sec14-GOLD    Structure    Multi-functions
收稿日期: 2018-07-30     
ZTFLH:  S435.661  
基金资助:国家自然科学基金(No.31671752,No.31101196)、福建省杰出青年基金(No.2015J06006)、福建省高校杰出青年科研人才计划项目(苏亚春-2017)和国家农业产业技术体系项目(CARS-17)
通讯作者: *,queyouxiong@126.com。   
引用本文:   
毛花英, 苏亚春, 阙友雄. 植物Sec14-like磷脂酰肌醇转运蛋白:变化的结构和多样的功能[J]. 农业生物技术学报, 2019, 27(2): 348-360.
MAO Hua-Ying, SU Ya-Chun, QUE You-Xiong. Plant Sec14-like Phosphatidylinositol Transfer Proteins: Diverse Structures and Multi-Functions. 农业生物技术学报, 2019, 27(2): 348-360.
链接本文:  
http://journal05.magtech.org.cn/Jwk_ny/CN/10.3969/j.issn.1674-7968.2019.02.018     或     http://journal05.magtech.org.cn/Jwk_ny/CN/Y2019/V27/I2/348
 
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