Research Progress on Copy Number Variation of Livestock and Poultry
JIN Mei-Lin1, LU Zeng-Kui2, LI Qing1, FEI Xiao-Juan1, CHU Ming-Xing1,*, WEI Cai-Hong1,*
1 Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China; 2 Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China
Abstract：Copy number variation (CNV) might be one main factor that affect the phenotypic diversity and evolutionary adaptation of animals. It uses a variety of mechanisms to regulate the body, such as changes in gene dose and transcription structure. Since the first generation CNV map of the human (Homo sapiens) genome was constructed, CNV has been increasingly studied in humans and animals. At present, studies have shown that CNV is related to the pathogenic mechanism of some human diseases, genetic variation of animals and important economic traits of domestic animals. In this paper, the definition, formation mechanism, detection method and research status of CNV for livestock and poultry were described based on relevant research reports at home and abroad. The problems faced by the research on CNV for livestock and poultry were summarized and the application prospect was prospected. This review provides reference materials for further research on CNV.
金美林, 卢曾奎, 李青, 费晓娟, 储明星, 魏彩虹. 畜禽拷贝数变异研究进展[J]. 农业生物技术学报, 2019, 27(10): 1840-1848.
JIN Mei-Lin, LU Zeng-Kui, LI Qing, FEI Xiao-Juan, CHU Ming-Xing, WEI Cai-Hong. Research Progress on Copy Number Variation of Livestock and Poultry. 农业生物技术学报, 2019, 27(10): 1840-1848.
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