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| Research Progress on the Regulation of Lipid Droplet Metabolism by Mitochondria |
| WANG Run-Yu1, YANG Lin-Xin1, ZHANG Rui-Qiang1, WANG Er-Dan1, YANG Cai-Mei2, YANG Ting1,3,* |
1 College of Animal Science and Technology•College of Veterinary Medicine/Zhejiang Key Laboratory of Applied Technology Research on Green-Ecological & Healthy Breeding of Livestock and Poultry/Zhejiang Engineering Laboratory of Animal Health Internet Detection Technology, Zhejiang Agricultural and Forestry University, Hangzhou 311300, China;
2 Zhejiang Vegamax Biotechnology Co., Ltd., Huzhou 313300, China;
3 Institute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang 330200, China |
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Abstract Mitochondria play a pivotal role in the energy metabolism of eukaryotic cells and are closely associated with lipid metabolism in adipose tissue. Lipid droplets maintain intimate connections with mitochondria and could form unique structural architectures; multiple proteins localized at the lipid droplet-mitochondria membrane contact sites are involved in regulating the biogenesis and expansion of lipid droplets. Mitophagy is categorized into 2 subtypes, namely ubiquitin-dependent mitophagy and ubiquitin-independent mitophagy, which could selectively eliminate damaged mitochondria to preserve cellular homeostasis. In adipocytes, mitophagy modulates mitochondrial quantity and adipocyte-specific properties, exerting profound impacts on lipid metabolism and systemic health. Although mitochondria and lipid droplets are of great significance in regulating lipid metabolism, preventing lipotoxicity, and maintaining lipid homeostasis, the current understanding of their interplay remains limited. This paper aims to broaden the insights into the mechanisms underlying the regulation of lipid metabolism by mitochondria-lipid droplet interactions, thereby providing theoretical foundations and research frameworks for elucidating the pathological mechanisms of metabolic diseases and developing targeted therapeutic strategies.
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Received: 25 March 2025
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Corresponding Authors:
*yangting@zafu.edu.cn
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