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| Research Progress on the Impact of Mitophagy on Oocyte |
| LI Na1, GAO Qian2, CUI Zhao-Kang3, HUANG Guang-Jun1, AN Zhen-Jiang1, MIAO Yi-Long1,* |
1 College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;
2 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China;
3 Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China |
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Abstract Mitochondrial autophagy plays a crucial role in cellular health and development. As a cellular autophagy mechanism, mitochondrial autophagy is responsible for the removal of damaged or dysfunctional mitochondria, ensuring cellular energy supply and metabolic balance. This article reviewed the latest research advancements in mitochondrial autophagy, focusing on the interplay between the PINK1/Parkin-dependent ubiquitin pathway and the ubiquitin-independent receptor-mediated autophagy mechanism. It also discussed the significance of mitochondrial autophagy in maintaining normal functions at the metabolic level in oocytes and in preserving mitochondrial quality in aging oocytes. Research indicated that mitochondrial autophagy not only effectively clears mutated mitochondrial DNA but also reduced oxidative stress, thereby enhancing the developmental potential of oocytes. By systematically summarizing the critical role of mitochondrial autophagy in oocyte development, this article provides new perspectives and strategies for optimizing reproductive technologies in both humans and animals, advancing further research and applications in the field.
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Received: 06 November 2024
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Corresponding Authors:
*miaoyilong@njau.edu.cn
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