IL-33/ST2信号通路影响干细胞功能的研究进展

doi:10.3969/j.issn.1674-7968.2024.04.014

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Abstract Interleucin 33 (IL-33) is a cytokine with both pro-inflammatory and anti-inflammatory functions, and its signaling is mediated through its specific receptor suppressor of tumorigenicity 2 (ST2). Activation of the IL-33/ST2 signaling pathway regulates NF-κb, TNFα, and Wnt signaling pathways depending on the cell type, thereby triggering inflammatory response and affecting the stemness and differentiation of stem cells. In this paper, the basic structure and composition of the IL-33/ST2 signaling pathway were reviewed, and the recent progress in stem cell function research was summarized. This review provides new ideas for the treatment of inflammatory and immune diseases by elucidating the mechanism of action of stem cells.

Key words： IL-33/ST2 signaling pathway Stem cell Cancer stem cell Cell therapy Inflammation

Received: 25 July 2023

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Corresponding Authors: *jinlianhua@nwsuaf.edu.cn

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	XU Wen-Jie
	HUA Jin-Lian

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XU Wen-Jie,HUA Jin-Lian. Research Progress on the Effect of IL-33/ST2 Signaling Pathway on Stem Cell Function[J]. 农业生物技术学报, 2024, 32(4): 892-902.

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https://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2024.04.014 OR https://journal05.magtech.org.cn/Jwk_ny/EN/Y2024/V32/I4/892

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