细胞泛凋亡的分子组成及作用机制

doi:10.3969/j.issn.1674-7968.2024.04.013

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Abstract Programmed cell death (PCD) is a line of the innate immune defense system, and plays an important role in the growth development and immune regulation of the organism. As a new PCD pathway, PANoptosis is regulated by the multi-protein complex PANoptosome, which can simultaneously regulate the three key modes of programmed cell death including pyroptosis, apoptosis and necrosis, thereby defending against invasion of various pathogens. Consequently, studying the mechanism of PANoptosis is of great significance for deepening the understanding of cell death patterns, suggesting the occurrence of inflammation and diseases. In this paper, the concept, mechanism of action, molecular composition and assembly method of PANoptosis were reviewed, then a view was proposed that the formation of PANoptosome was a sign of PANoptosis in cells. This review provides new ideas for the treatment of inflammatory diseases.

Key words： PANoptosis PANoptosome Apoptosis Necrosis Pyroptosis

Received: 19 June 2023

ZTFLH:	S8
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Corresponding Authors: *wangshumin@cau.edu.cn

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	WANG Yi-Ru
	WANG Yuan
	CAO Ling-Xia
	YANG Jie
	WANG Shu-Min

Cite this article:

WANG Yi-Ru,WANG Yuan,CAO Ling-Xia, et al. Molecular Composition and Mechanism of Action of PANoptosis[J]. 农业生物技术学报, 2024, 32(4): 882-891.

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https://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2024.04.013 OR https://journal05.magtech.org.cn/Jwk_ny/EN/Y2024/V32/I4/882

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