摘要α-生育酚转移蛋白(α-tocopherol transfer protein, α-TTP)是决定机体维生素E含量的重要蛋白，对于维生素E在肝脏中沉积及向外周组织转运起着关键调控作用。α-TTP基因突变后可引发维生素E缺乏性共济失调症，导致血浆中维生素E含量极低，同时伴随有进行性神经退化症状。本文重点综述了α-TTP的生理功能、作用机制以及维生素E对α-TTP表达影响的研究进展，并对其未来的研究方向进行了展望，从而为α-TTP转运α-生育酚的分子机制研究及维生素E吸收、代谢途径等相关研究提供理论参考。
Abstract：The α-tocopherol transfer protein (α-TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E in hepatocytes and facilitates the secretion of tocopherol from hepatocytes to extrahepatic tissues. Heritable mutations in α-TTP gene cause ataxia with vitamin E deficiency (AVED), which characterized by low plasma vitamin E levels and progressive neurodegeneration. This review focused on the function and molecular aspects of α-TTP activity as well as the effect of vitamin E on the expression of α-TTP. In the end, further research focuses were also discussed. Overall, this review may provide theoretical references for α-TTP and vitamin E metabolism research.
