Mechanisms of Shikonin's Antimicrobial Action and Its Applications in Animal Production
WANG Yi-Ping1,2, ZHOU Xiao-Jie1, LIU Jing-Ya1, HUANG Xin-Li1, LAN Ying1, LIU Ben1,2,*, ZHENG Wen-Ya1,2
1 School of Life Sciences and Environmental Resources, Yichun University, Yichun 336000, China; 2 Research Center for Traditional Chinese Veterinary Medicine and Animal Embryo Engineering Technology, Yichun University, Yichun 336000, China
Abstract：Shikonin, a highly liposoluble naphthoquinone compound isolated from the dried roots of Lithospermum erythrorhizon, has been demonstrated to possess multiple biological functions, including antimicrobial, anti-inflammatory, anti-heat stress, and wound-healing promoting activities. Given its unique bioactive properties, this compound exhibits significant application potential in green antibiotic-free fields such as alleviating transport stress in livestock and poultry, promoting animal wound repair, developing feed additives, advancing the development of antibiotic-free feed, and food preservation. Therefore, this article comprehensively reviewed the mechanisms of action of shikonin against pathogenic microorganisms and summarized its potential applications and research findings in livestock production, including its role in alleviating transport stress, promoting wound repair, and serving as a feed additive. The review provides a reference for the development and utilization of shikonin in animal production.
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