Research Progress on Histone Lactylation in Animal Reproductive Development
XIA Yi, WANG Zhi-Chao, SHI Zhen-Hu, WANG Xin, ZHANG Yun-Hai*, CAO Zu-Bing*
Anhui Provincial Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Breeding/College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Abstract：Epigenetic modification plays an important role in a series of reproductive developments such as spermatogenesis, oogenesis, early embryonic development, embryo implantation, and stem cells. Histone lactylation, as a newly discovered epigenetic modification that links cellular metabolism with epigenetic regulation, is gradually deepening the study of its mechanism of action in animal reproductive development. In this paper, the latest research progress on histone lactylation were summarized, focusing on the close relationship between histone lactylation and other apparent modifications, the writer, reader and eraser of histone lactylation modifications, and the role of histone lactylation in animal reproductive development. This paper systematically reviewed the research progress of histone lactylation modification in animal repro-ductive development, provides a theoretical basis for a deeper understanding of the molecular regulatory mechanisms of reproductive development.
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