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| Research Progress on Regulation of Endoplasmic Reticulum-Lipid Droplet-Mitochondrial Interactions in Animal Lipid Metabolism |
| WANG Ming-Yu, PANG Wei-Jun, CAI Rui* |
| Animal Fat Deposition and Muscle Development Laboratory, College of Animal Science and Technology, Northwest A＆F University, Yangling 712100, China |
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Abstract Lipid droplet (LD), endoplasmic reticulum (ER) and mitochondria are key organelles in animal cells, and their interaction plays an important role in regulating animal lipid metabolism. ER interacts with LD to promote LD outgrowth, growth, and lipid transfer, so that LD can be efficiently stored and distributed to maintain cellular energy balance and lipid homeostasis. In addition, the interaction between LD and mitochondria promotes the efficient uptake of free fatty acids (FFAs) by mitochondria, which helps to maintain cellular energy supply. This review focuses on LD, and summarize the interactions between LD and mitochondria, ER, peroxisomes, lysosomes, and other organelles, as well as the advances of the regulation of in animal lipid metabolism. This review provides a new way of investigating lipid metabolism from the perspective of organelles, as well as a new direction for the analysis of the mechanism of formation of livestock and poultry meat traits and treatment of metabolic diseases in human (Homo sapiens).
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Received: 22 November 2023
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Corresponding Authors:
* cairui1663@nwafu.edu.cn
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