|
|
Research Progress of Long Non-coding RNA in Intestinal Diseases of Livestock and Poultry |
GAO Xiao-Li1, HUANG Xiao-Yu1, YANG Qiao-Li1, ZHANG Sheng-Wei2, GUN Shuang-Bao1,2,* |
1 College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China; 2 Gansu Research Center for Swine Production Engineering and Technology, Lanzhou 730070, China |
|
|
Abstract Long non-coding RNA (lncRNA) is an important class of functional non-coding RNA, which can regulate physiological processes such as cell proliferation, differentiation and metabolism, and participate in the regulation of various pathological processes in the body. In the rapid development of the intensive breeding industry, the intestinal diseases of livestock and poultry have a high incidence and mortality that seriously affect the health of livestock and poultry and cause significant economic losses to animal production industry. In recent years, many lncRNAs associated with intestinal inflammation and diseases have been identified by transcriptome sequencing technology. Researches on human (Homo sapiens) and mouse (Mus musculus) model organisms demonstrated that multiple lncRNAs are abnormally expressed in intestinal diseases, which regulate the expression and distribution of tight junction proteins, and also participate in the production of various inflammatory molecules and the activation of signaling pathways. In this paper, the regulatory function of lncRNA in intestinal barrier and immune-homeostasis, and the recent research progresses in livestock and poultry were reviewed. This review offers references for the follow-up research on resistance to intestinal diseases in livestock and poultry and the breeding of resistant varieties.
|
Received: 04 November 2019
|
|
Corresponding Authors:
*, gunsb@gsau.edu.cn
|
|
|
|
[1] 黄艳芬, 刘湘红, 伍浩, 等. 2019. 肠黏膜屏障与肠道菌群的相互关系[J].中国微生态学杂志, 31(12): 1465-1469+1474. (Huang Y F, Liu X H, Wu H, et al. 2019. The relationship between intestinal mucosal barrier and intestinal microflora[J]. Chinese Journal of Microecology, 31(12): 1465-1469+1474.) [2] 李帅, 董震, 王晓晨, 等. 2020. LncRNA FZD10-AS1通过调控miR-337-3p/GPD1分子轴抑制骨肉瘤细胞的增殖和迁移[J]. 实用医学杂志, 36(03): 294-298. (Li S, Dong Z, Wang X C, et al.2020. LncRNA FZD10-AS1 inhibits proliferation and migration of osteosarcoma cells by regulating miR-337-3p/GPD1 molecular axis[J]. The Journal of Practical Medicine, 36(03): 294-298.) [3] 刘路路, 邹松, 钱小宝, 等. 2017. 长链非编码RNA在脂多糖刺激的大鼠肠巨噬细胞中的差异表达[J]. 中国普通外科杂志, 2017, 26(04): 488-493. (Liu L L, Zou S, Qian X B, et al.2017. Differential expression of lncRNA in intestinal rat macrophages treated with lipopolysaccharide[J]. Chinese Journal of General Surgery, 2017, 26(04): 488-493.) [4] 刘志宇, 曹安, 蒋林树, 等. 2018. 长链非编码RNA(lncRNA)生物学功能及其调控机制[J]. 农业生物技术学报, 26(08): 1419-1430. (Liu Z Y, Cao A, Jiang L S, et al.Biological function and regulatory mechanism of long non-coding RNA (lncRNA)[J]. Journal of Agricultural Biotechnology, 26(08): 1419-1430.) [5] 马齐蔓. 2018. BVDV感染MDBK细胞的lncRNA文库构建及lncRNA 1620调控细胞凋亡的研究[D]. 石河子大学, 导师: 陈创夫, pp.120. (Ma Q M. 2018. Study on construction of lncRNA library of BVDV infected MDBK cells and the regulation of apoptosis by lncRNA 1620[D]. Thesis for Ph.D., Shihezi University, Supervisor: Chen C F, pp. 120.) [6] 肖克权, 高凤仙. 2019. 热应激对生长猪生长性能、生理、肠道黏膜屏障功能的影响[J]. 家畜生态学报, 40(01): 7-12. (Xiao K Q, Gao F X.2019. Effect of heat stress on growth performance, plysiology and intestinal mucosal barrier in growing pigs[J]. Acta Ecologiae Animalis Domastici, 40(01): 7-12.) [7] 王海珍, 李步高, 高鹏飞. 2019. 哺乳动物肠上皮屏障中非编码RNAs的调控作用[J]. 中国生物化学与分子生物学报, 35(12): 1333-1340. (Wang H Z, Li B G, Gao P F.2019. Regulation of non-coding RNAs in the intestinal epithelial barrier in mammals[J]. Chinese Journal of Biochemistry and Molecular Biology, 35(12): 1333-1340.) [8] 王婷梅, 曲丽娜, 李莹辉. 2015. LncRNA的结构、功能及其与疾病的关系[J]. 中国生物化学与分子生物学报, 7: 659-666. (Wang T M, Qu L N, Li Y H.2015. Structures and functions of long non-coding RNAs and its roles in diseases[J]. Chinese Journal of Biochemistry and Molecular Biology, 7: 659-666.) [9] 王亚南. 2018. 肠炎沙门氏菌感染后SPF白来航鸡和济宁百日鸡盲肠lncRNA表达谱分析[D]. 硕士学位论文, 山东农业大学, 导师: 李显耀, pp. 35-43. (Wang Y N.2018. Analysis of the cecal lncRNA expression profile in SPF white leghorn and jining bairi chicken after Salmonella enteric serovar enteritidis infection[D]. Thesis for M.S., Shandong Agricultural University, Supervisor: Li X Y, pp. 35-43.) [10] 呙于明, 刘丹, 张炳坤. 2014. 家禽肠道屏障功能及其营养调控[J]. 动物营养学报, 26(10): 3091-3100. (Wo Y M, Liu D, Zhang B K.2014. Intestinal barrier of poultry: Function and modulation[J]. Chinese Journal of Animal Nutrition, 26(10): 3091-3100.) [11] 吴正常. 2017. 断奶仔猪F18大肠杆菌抗性基因和lncRNA的筛选与调控机制分析[D].博士学位论文, 扬州大学, 导师:王金玉, PP. 72-91. (Wu Z C.2017. Screening and regulatory mechanism analysis of genes and lncRNA related to E.coli F18 resistance in weaned piglets[D]. Thesis for Ph.D., Yangzhou University, Supervisor: Wang J Y, pp. 42-96. ) [12] 姚俊, 许亚平, 石岩. 2018. 非编码RNA在炎症性肠病中的研究进展[J]. 临床与病理杂志, 38(09): 1990-1996. (Yao J, Xu Y P, Shi Y.2018. Research progress of non-coding RNA in inflammatory bowel disease[J]. Journal of Clinical and Pathological Research, 38(09): 1990-1996.) [13] 赵宁. 2016. 产肠毒素性大肠杆菌感染小鼠致腹泻LncRNA表达谱的构建[D]. 硕士学位论文, 宁夏大学, 导师: 邓光存, pp. 30-44. (Zhao N.2016. LncRNA expression signatures in response to enterotoxigenic Escherichia coli infection in mice[D]. Thesis for M.S., Ningxia University, Supervisor: Deng G C, pp. 30-44.) [14] Beltran M, Puig I, Peña C, et al.2008. A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epotheliala mesenchymal transition[J]. Genes and Development, 22(6): 756-69. [15] Cabili M N, Trapnell C, Goff L, et al.2011. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses[J]. Genes and Development, 25(18): 1915-1927. [16] Castellanos-Rubio A, Kratchmarov R, Sebastian M, et al.2017. Cytoplasmic form of Carlr lncRNA facilitates inflammatory gene expression upon NF-κB activation[J]. Journal of Immunology, 199: 581-588. [17] Chen S W, Wang P Y, Liu Y C, et al.2016. Effect of long noncoding RNA H19 overexpression on intestinal barrier function and its potential role in the pathogenesis of Ulcerative Colitis[J]. Inflammatory Bowel Diseases, 22(11): 2582. [18] Chen J, Wan J H, Ye J F, et al.2018. Emerging role of lncRNAs in the normal and diseased intestinal barrier[J]. Inflammation Research, 67: 757-764. [19] Chen J N, Zhang C Y, Zhang N, et al.2019. Porcine endemic diarrhea virus infection regulates long noncoding RNA expression[J]. Virology, 527: 89-97. [20] Chen T, Xue H, Lin R, et al.2017. MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease[J]. Biochemical and Biophysical Research Communications, 486(1): 6-13. [21] Dokladny K, Ye D, Kennedy J C, et al.2008. Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: Regulatory role of heat shock factor-1[J]. American Journal of Pathology, 172(3): 659-670. [22] Fang M X, Yang Y, Wang N D, et al.2019. Genome-wide analysis of long non-coding RNA expression profile in porcine circovirus 2-infected intestinal porcine epithelial cell line by RNA sequencing[J]. Peer J, 7: e6577. [23] Fatica A, Bozzoni I.2014. Long non-coding RNAs: New players in cell differentiation and development[J]. Nature Reviews Genetics, 15(1): 7-21. [24] Flynn R A, Chang H Y.2014. Long noncoding RNAs in cell-fate programming and reprogramming[J]. Cell Stem Cell, 14(6): 752-761. [25] Galán J E.1998. Interactions of Salmonella with host cells: Encounters of the closest kind[J]. Proceedings of the National Academy of Sciences of the USA, 95(24): 14006-14008. [26] Heo J B, Lee Y S, Sung S.2013. Epigenetic regulation by long noncoding RNAs in plants[J]. Science, 21(6-7): 685-693. [27] Huang B, Zhang R.2014. Regulatory non-coding RNAs: Revolutionizing the RNA world[J]. Molecular Biology Reports, 41(6): 3915-3923. [28] Huang X Y, Sun W Y, Yan Z Q, et al.2019. Novel insights reveal anti-microbial gene regulation of piglet intestine immune in response to Clostridium perfringens Infection[J]. Scientific Reports, 9(1): 1963. [29] Jandura A, Krause H M.2017. The new RNA world: Growing evidence for long noncoding RNA functionality[J]. Trends in Genetics, 33(10): 665-676. [30] Jin C Y, Bao J J,Wang Y, et al.2018. Changes in long non-coding RNA expression profiles related to the antagonistic effects of Escherichia coli F17 on lamb spleens[J]. Scientific Reports, 8: 16514. [31] Kameswaran V, Kaestner K H.2014. The missing lncRNA between the pancreatic beta-cell and diabetes[J]. Frontiers in Genetics, 5: 200. [32] Kino T, Hurt D E, Ichijo T, et al.2010. Noncoding RNA gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor[J]. Science Signaling, 3(107): ra8. [33] Lee J T, Bartolomei M S.2013. X-inactivation, imprinting, and long noncoding RNAs in health and disease[J]. Cell, 152(6): 1308-1323. [34] Lipovich L, Johnson R, Lin C Y.2010. MacroRNA underdogs in a microRNA world: Evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA[J]. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1799(9): 597-615. [35] Liu R, Tang A L, Wang X Y, et al.2018a. Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages[J]. International Journal of Molecular Medicine, 42(5): 2903-2913. [36] Liu T L, Fan X C, Li Y H, et al.2018b. Expression profiles of mRNA and lncRNA in HCT-8 Cells Infected With Cryptosporidium parvum IId Subtype[J]. Frontiers in Microbiology, 9: 1409. [37] López-ortega O, Ovalle-garcía E, Ortega-blake I, et al.2016. Myo1g is an active player in maintaining cell stiffness in B-lymphocytes[J]. Cytoskeleton, 73(5): 258-268. [38] Ma D, Cao Y Y, Wang Z H, et al.2019. CCAT1 lncRNA promotes inflammatory bowel disease malignancy by destroying intestinal barrier via downregulating miR-185-3p[J]. Inflammatory Bowel Diseases, 25(5): 862-874. [39] Ma Q M, Li L Y, Tang Y, et al.2017. Analyses of long non-coding RNAs and mRNA profiling through RNA sequencing of MDBK cells at different stages of Bovine viral diarrhea virus infection[J]. Research in Veterinary Science, 115: 508-516. [40] Mercer T R, Dinger M E, Marcel J S.2009. Long non-coding RNAs: Insights into functions[J]. Nature Reviews. Genetics, 10(3):155-159. [41] Miao L, Gong Y, Li H, et al.2020. Alterations in cecal microbiota and intestinal barrier function of laying hens fed on fluoride supplemented diets[J]. Ecotoxicology and Environment Safety, 193: 110372. [42] Niessen C M.2007. Tight junctions/adherens junctions: Basic structure and function[J]. The Journal of Investigative Dermatology, 127(11): 2525-2532. [43] Ozden O, Black B L, Ashwell C M, et al.2010. Developmental profile of claudin-3, -5, and-16 proteins in the epithelium of chick intestine[J]. Gastrointestinal Biology, 293(7): 1175-1183. [44] Park J Y, Lee J E, Park J B, et al.2014. Roles of long non-coding RNAs on tumorigenesis and glioma development[J]. Brain Tumor Research and Treatment, 2(1): 1-6. [45] Pauli A, Valen E, Lin M F, et al.2012. Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis[J]. Genome Research, 22(3): 577-591. [46] Peterson L W, Artis D.2014. Intestinal epithelial cells: Regulators of barrier function and immune homeostasis[J]. Nature Reviews Immunology, 14(3): 141-153. [47] Ponting C P, Oliver P L, Reik W.2009. Evolution and functions of long noncoding RNAs[J]. Cell, 136(4): 629-641. [48] Quan Y, Song K, Zhang Y, et al.2018. Roseburia intestinalis-derived flagell in is a negative regulator of intestinal inflammation[J]. Biochemical and Biophysical Research Communications, 501(3): 791-799. [49] Rankin C R, Iliopoulos D, Pothoulakis C, et al.2017. Gene expression profiling identifies CDKN2B-AS1 as a long non-coding RNA associated with IBD and regulated by TGF-β[J]. Gastroenterology, 152(5), S144. [50] Rankin C R, Lokhandwala Z A, Huang R, et al.2019. Linear and circular CDKN2B-AS1 expression is associated with inflammatory bowel disease and participates in intestinal barrier formation[J]. Life Sciences. 231: 116571 [51] Santin I, Jauregi-Miguel A, Velayos T, et al.2018. Celiac disease-associated lncRNA named HCG14 regulates NOD1 expression in intestinal cells[J]. Journal of Pediatric Gastroenterology and Nutrition, 67(2): 225-231. [52] Su Z, Zhi X, Zhang Q, et al.2016. LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier[J]. FEBS Letters, 590(9): 1354-1364. [53] Suzuki T.2013. Regulation of intestinal epithelial permeability by tight junctions[J]. Cellular and Molecular Life Sciences, 70(4): 631-659. [54] Tang X Y, Lan T, Wu R T, et al.2019. Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection[J]. BMC Veterinary Research, 15(1): 111. [55] Tsai M C, Manor O, Wan Y, et al.2010. Long noncoding RNA as modular scaffold of histone modification complexes[J]. Science, 329(5992): 689-693. [56] Turner J R.2009. Intestinal mucosal barrier function in health and disease[J]. Nature Reviews Immunology, 9(11): 799-809. [57] Vicente Y, Da Rocha C, Yu J, et al.2001. Architecture and function of the gastroesophageal barrier in the piglet[J]. Digestive Diseases and Sciences, 46(9): 1899-1908. [58] Wang J Y, Xiao L, Chung H K, et al.2017. Long noncoding RNA UC-173 enhances gut barrier functionby promoting translation of tight junction claudin-1[J]. Gastroenterology, 152(5): s119. [59] Wang X, Arai S, Song X, et al.2008. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription[J]. Nature, 454(7200): 126. [60] Wilk R, Hu J, Blotsky D, et al.2016. Diverse and pervasive subcellular distributions for both coding and long noncoding RNAs[J]. Genes and Development, 30: 594-609. [61] Wu F, Huang Y, Dong F, et al.2016. Ulcerative colitis-associated long noncoding RNA, BC012900, regulates intestinal epithelial cell apoptosis[J]. Inflammatory Bowel Diseases, 22(4): 782-795. [62] Wu X, Brewer G.2012. The regulation of mRNA stability in mammalian cells: 2.0[J]. Gene, 500(1): 10-21. [63] Xiao L, Jaladanki R N, Wu J, et al.2015. Long noncoding RNA PTENP1 competes with miR-29b to regulate JAM-A expression and intestinal epithelial barrier function[J]. Gastroenterology, 148(4): s344. [64] Xiao L, Rao J N, Cao S, et al.2016. Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins[J]. Molecular Biology of the Cell, 27: 617-626. [65] Yan Z Q, Huang X Y, Sun W Yet al.2018. Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by Clostridium perfringens type C[J]. Peer J, 6: e5997. [66] Yan X, Zhang D, Wu W, et al.2017. Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a[J]. Cancer Research, 77(23): 6704-6716. [67] Zhang X D, Huang G W, Xie Y H, et al.2018. The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells[J]. Nucleic Acids Research, 46(4): 1793-1809. [68] Zhang X T, Gong A Y, Wang Y, et al.2016. Cryptosporidium parvum infection attenuates the ex vivo propagation of murine intestinal enteroids[J]. Physiological Reports, 4: e13060. |
|
|
|