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| Advances in BMP15 Gene Research |
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Abstract Abstract Bone morphogenetic protein 15 (BMP15) is one member of the transforming growth factor-β (TGF-β) superfamily, also known as GDF9B for its similarity in protein structure and biological function with the growth differentiation factor 9 (GDF9), another member of the TGF-β superfamily. As an oocyte-secreted factor (OSF), BMP15 can form biologically active homodimers or heterodimers with GDF9 through non-covalent interactions, to bind to specific receptors BMPR1B and/or BMPR2 expressed on the ovarian cell membrane, playing an important role in the regulation of mammalian ovarian functions and fertility, including the promotion of follicle growth and maturation from gonadotrophin-independent stages; BMP15 gene has been identified as one of the major genes controlling ovulation rate in multiparous sheep. This review summarizes the common and differing functions of BMP15 gene between different mammalian species, aiming at providing a useful information for further study on the regulatory role of BMP15 gene on female ovarian functions. In addition, based on the rapid development of genome editing technology, prolific livestock breed is hoped to be produced in future through precise modifications on BMP15 gene.
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Received: 19 April 2016
Published: 13 January 2017
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| Abir R, Fisch B, and Johnson MH 2014. BMP15, fertility and the ovary[J]. Reproductive Biomedicine Online, 29(5): 525-526.Al-Musawi SL, Walton KL, Heath D, et al. 2013. Species differences in the expression and activity of bone morphogenetic protein 15[J]. Endocrinology, 154(2): 888-899.Barnett KR, Schilling C, Greenfeld CR, et al. 2006. Ovarian follicle development and transgenic mouse models[J]. Human Reproduction Update, 12(5): 537-555.Cerra C, Oliver J, Roberts SA, et al. 2014. A single nucleotide polymorphism of bone morphogenic protein-15 is not associated with ovarian reserve or response to ovarian stimulation[J]. Human Reproduction, 29(12): 2832-2837.Chang HM, Cheng J-C, Taylor E, et al. 2014. Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells[J]. Molecular Human Reproduction, 20(5): 373-383.Chang HM, Cheng JC, Klausen C, et al. 2013. BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells[J]. Molecular Endocrinology, 27(12): 2093-2104.Cong L, Ran FA, Cox D, et al. 2013. Multiplex genome engineering using CRISPR/Cas systems[J]. Science, 339(6121): 819-823.Crawford JL, and McNatty KP 2012. The ratio of growth differentiation factor 9: Bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates[J]. Molecular and Cellular Endocrinology, 348(1): 339-343.Di Pasquale E, Beck-Peccoz P, and Persani L 2004. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene[J]. American Journal of Human Genetics, 75(1): 106-111.Dube JL, Wang P, Elvin J, et al. 1998. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes[J]. Molecular Endocrinology, 12(12): 1809-1817.Ducy P, and Karsenty G 2000. The family of bone morphogenetic proteins[J]. Kidney International, 57(6): 2207-2214.Epifano O, and Dean J 2002. Genetic control of early folliculogenesis in mice[J]. Trends in Endocrinology and Metabolism, 13(4): 169-173.Eppig JJ, Wigglesworth K, and Pendola FL 2002. The mammalian oocyte orchestrates the rate of ovarian follicular development[J]. Proceedings of the National Academy of Sciences, 99(5): 2890-2894.Fonseca DJ, Ortega-Recalde O, Esteban-Perez C, et al. 2014. BMP15 c.-9C>G promoter sequence variant may contribute to the cause of non-syndromic premature ovarian failure[J]. Reproductive Biomedicine Online, 29(5): 627-633.Galloway SM, McNatty KP, Cambridge LM, et al. 2000. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner[J]. Nature Genetics, 25(3): 279-283.Gilchrist RB, Lane M, and Thompson JG 2008. Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality[J]. Human Reproduction Update, 14(2): 159-177.Gilchrist RB, Ritter LJ, and Armstrong DT 2004. Oocyte-somatic cell interactions during follicle development in mammals[J]. Animal Reproduction Science, 82-83: 431-446.He Z, Shi X, Du B, et al. 2015. Highly efficient enrichment of porcine cells with deletions induced by CRISPR/Cas9 using dual fluorescence selection[J]. Journal of Biotechnology, 214: 69-74.Hussein TS, Froiland DA, Amato F, et al. 2005. Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins[J]. Journal of Cell Science, 118(22): 5257-5268.Hussein TS, Thompson JG, and Gilchrist RB 2006. Oocyte-secreted factors enhance oocyte developmental competence[J]. Developmental Biology, 296(2): 514-521.Inagaki K, and Shimasaki S 2010. Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion[J].Molecular and Cellular Endocrinology, 328(1-2): 1-7.Juengel JL, Bodensteiner KJ, Heath DA, et al. 2004. Physiology of GDF9 and BMP15 signalling molecules[J]. Animal Reproduction Science, 82-83(447-460.Juengel JL, Hudson NL, Berg M, et al. 2009. Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle[J]. Reproduction, 138(1): 107-114.Kathirvel M, Soundian E, and Kumanan V 2013. Differential expression dynamics of Growth differentiation factor9 (GDF9) and Bone morphogenetic factor15 (BMP15) mRNA transcripts during in vitro maturation of buffalo (Bubalus bubalis) cumulus-oocyte complexes[J]. Springerplus, 2(1): 206.Kerr JB, Myers M, and Anderson RA 2013. The dynamics of the primordial follicle reserve[J]. Reproduction, 146(6): R205-R215.Knight PG, and Glister C 2006. TGF-β superfamily members and ovarian follicle development[J]. Reproduction, 132(2): 191-206.Lan ZJ, Gu PL, Xu XP, et al. 2003. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility[J]. Embo Journal, 22(16): 4070-4081.Li Q, Rajanahally S, Edson MA, et al. 2009. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15[J]. Molecular Human Reproduction, 15(12): 779-788.Liao WX, Moore RK, Otsuka F, et al. 2003. Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9 Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep[J]. Journal of Biological Chemistry, 278(6): 3713-3719.Liu J, Wang BB, Wei ZL, et al. 2011. Mutational analysis of human bone morphogenetic protein 15 in Chinese women with polycystic ovary syndrome[J]. Metabolism-Clinical and Experimental, 60(11): 1511-1514.Margulis S, Abir R, Felz C, et al. 2009. Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women[J]. Fertility and Sterility, 92(5): 1666-1673.Matzuk MM, Burns KH, Viveiros MM, et al. 2002. Intercellular communication in the mammalian ovary: oocytes carry the conversation[J]. Science, 296(5576): 2178-2180.Monestier O, Servin B, Auclair S, et al. 2014. Evolutionary origin of bone morphogenetic protein 15 and growth and differentiation factor 9 and differential selective pressure between mono- and polyovulating species[J]. Biology of Reproduction, 91(4): 83.Monniaux D, Clément F, Dalbiès-Tran R, et al. 2014. The ovarian reserve of primordial follicles and the dynamic reserve of antral growing follicles: what is the link?[J]. Biology of Reproduction, 90(4): 85.Montgomery GW, Galloway SM, Davis GH, et al. 2001. Genes controlling ovulation rate in sheep[J]. Reproduction, 121(6): 843-852.Moore RK, Erickson GF, and Shimasaki S 2004. Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?[J]. Trends in Endocrinology and Metabolism, 15(8): 356-361.Moore RK, Otsuka F, and Shimasaki S 2003. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells[J]. Journal of Biological Chemistry, 278(1): 304-310.Moron FJ, de Castro F, Royo JL, et al. 2006. Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)[J]. Pharmacogenet Genomics, 16(7): 485-495.Otsuka F, Moore RK, Iemura S, et al. 2001a. Follistatin inhibits the function of the oocyte-derived factor BMP-15[J]. Biochemical and Biophysical Research Communications, 289(5): 961-966.Otsuka F, and Shimasaki S 2002a. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis[J]. Proceedings of the National Academy of Sciences, 99(12): 8060-8065.Otsuka F, and Shimasaki S 2002b. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes[J]. Endocrinology, 143(12): 4938-4941.Otsuka F, Yamamoto S, Erickson GF, et al. 2001b. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression[J]. Journal of Biological Chemistry, 276(14): 11387-11392.Otsuka F, Yao Z, Lee T H, et al. 2000. Bone morphogenetic protein-15 Identification of target cells and biological functions[J]. Journal of Biological Chemistry, 275(50): 39523-39528.Passos MJ, Vasconcelos GL, Silva AW, et al. 2013. Accelerated growth of bovine preantral follicles in vitro after stimulation with both FSH and BMP-15 is accompanied by ultrastructural changes and increased atresia[J]. Theriogenology, 79(9): 1269-1277.Paulini F, and Melo EO 2011. The Role of Oocyte-Secreted Factors GDF9 and BMP15 in Follicular Development and Oogenesis[J]. Reproduction in Domestic Animals, 46(2): 354-361.Persani L, Rossetti R, Di Pasquale E, et al. 2014. The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders[J]. Human Reproduction Update, 20(6): 869-883.Pramod RK, Sharma SK, Singhi A, et al. 2013. Differential ovarian morphometry and follicular expression of BMP15, GDF9 and BMPR1B influence the prolificacy in goat[J]. Reproduction in Domestic Animals, 48(5): 803-809.Prapa E, Vasilaki A, Dafopoulos K, et al. 2015. Effect of Anti-Mullerian hormone (AMH) and bone morphogenetic protein 15 (BMP-15) on steroidogenesis in primary-cultured human luteinizing granulosa cells through Smad5 signalling[J]. Journal of Assisted Reproduction and Genetics, 32(7): 1079-1088.Pulkki MM, Myllymaaa S, Pasternack A, et al. 2011. The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: Characterization of the purified untagged processed mature region[J]. Molecular and cellular endocrinology, 332(1-2): 106-115.Rossetti R, Di Pasquale E, Marozzi A, et al. 2009. BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein[J]. Human Mutation, 30(5): 804-810.Shimasaki S, Moore RK, Otsuka F, et al. 2004. The bone morphogenetic protein system in mammalian reproduction[J]. Endocrine Reviews, 25(1): 72-101.Silva JR, van den Hurk R, van Tol HT, et al. 2005. Expression of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and BMP receptors in the ovaries of goats[J]. Molecular Reproduction and Development, 70(1): 11-19.Song Y, Zeng Y, Chen W, et al. 2010. Genetic variants of BMP 15 and BMPR-IB genes and association with litter size in pig[J]. Journal of Zhejiang University(Agriculture and Life Sciences), 36(5): 561-567.Su YQ, Sugiura K, Li Q, et al. 2010. Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling[J]. Molecular Endocrinology, 24(6): 1230-1239.Su YQ, Sugiura K, Wigglesworth K, et al. 2008. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells[J]. Development, 135(1): 111-121.Su YQ, Wu X, O'Brien MJ, et al. 2004. Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop[J]. Developmental Biology, 276(1): 64-73.Sugiura K, Su YQ, Diaz FJ, et al. 2007. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells[J]. Development, 134(14): 2593-2603.Sugiura K, Su YQ, Li Q, et al. 2010. Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15[J]. Molecular Endocrinology, 24(12): 2303-2314.Suh CS, Sonntag B, and Erickson GF 2002. The ovarian life cycle: a contemporary view[J]. Reviews in Endocrine &Metabolic Disorders, 3(1): 5-12.Sutton-McDowall ML, Mottershead DG, Gardner DK, et al. 2012. Metabolic Differences in Bovine Cumulus-Oocyte Complexes Matured In Vitro in the Presence or Absence of Follicle-Stimulating Hormone and Bone Morphogenetic Protein 15[J]. Biology of Reproduction, 87(4).Tibaldi E, Arrigoni G, Martinez HM, et al. 2010. Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9[J]. FEBS Letters, 584(4): 801-805.Urist MR 1965. Bone: formation by autoinduction[J]. Science, 150(3698): 893-899.Vitt UA, Mazerbourg S, Klein C, et al. 2002. Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9[J]. Biology of Reproduction, 67(2): 473-480.Wigglesworth K, Lee KB, Emori C, et al. 2015. Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles[J]. Biology of Reproduction, 92(1): 23.Wigglesworth K, Lee KB, O'Brien MJ, et al. 2013. Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes[J]. Proceedings of the National Academy of Sciences, 110(39): E3723-E3729.Wu YT, Tang L, Cai J, et al. 2007. High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development[J]. Human Reproduction, 22(6): 1526-1531.Xiao YT, Xiang LX, and Shao JZ 2007. Bone morphogenetic protein[J]. Biochemical and Biophysical Research Communications, 362(3): 550-553.Yan C, Wang P, DeMayo J, et al. 2001. Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function[J]. Molecular Endocrinology, 15(6): 854-866.Zhai B, Liu H, Li X, et al. 2013. BMP15 Prevents Cumulus Cell Apoptosis Through CCL2 and FBN1 in Porcine Ovaries[J]. Cellular Physiology and Biochemistry, 32(2): 264-278.Zhao L, Du X, Huang K, et al. 2016. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice[J]. Scientific Reports, 6(23972. |
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