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| Reviews on Wnt Signaling Pathway and Its Regulation in Skeletal Muscle Development |
| FU Yu1, DONG Xin-Xing2, YAN Da-Wei2, ZHANG Hao1, ZHANG Bo1,* |
1 National Engineering Laboratory for livestock and poultry breeding / Plateau Animal Genetic Resources Center, China Agricultural University, Beijing 100193, China;
2 College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China |
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Abstract Wnt is a secreted glycoprotein, which can bind to receptors in the form of paracrine or autocrine, activate intracellular signaling pathways, regulate target gene transcription, and then participate in the regulation of various cytological processes such as embryonic development and cell proliferation, especially playing an important role in skeletal muscle development. In this review, Wnt protein receptors and Wnt signaling pathways were reviewed, and the regulatory roles of Wnt pathways in skeletal muscle development and regeneration were expounded from the perspectives of ligands, regulatory factors and interactions with other pathways. This review not only provides ideas for the study of research on the regulation mechanism of skeletal muscle growth and development, but also lays a theoretical foundation for animal husbandry production.
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Received: 20 April 2021
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Corresponding Authors:
*bozhang06@126.com
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