Contact Us Add to Favorite
 
NianQi Search Adv Search
33
研究论文 Current Issue | Archive | Adv Search |
Expression of Mutant Tumor Suppressor Gene p53 in Egg-type Chicken
 Infected with Avian Leukosis Viruse Subgroup J
Xu Binrui1 Dong Weixing2 He Zhaoqing1 Yu Chunming1 Li Ning1
Feng Xiaoyu 1 L.F. Lee3 Maoxiang Li3
(1. College of Animal Medicine, China Agricultural University , Beijing 100094, China; 2. Animal Husbandry Bureau, Anhui Agricultural Committee, Hefei 230001 ,China; 3. Avian Disease and Oncology Laboratory, United States Department of Agriculture,East Lansing, MI 48823, USA)
Download: PDF (508 KB)   HTML (1 KB) 
Export: BibTeX | EndNote (RIS)      
Abstract  Abstract:Avian leukosis in egg-type chickens is infectious neoplastic disease caused by avian leukosis viruse subgroup J( ALV-J). Expression of mutant tumor suppressor gene p53 in egg-type chicken with avian leukosis subgroup J was detected to study cancericidally molecular mechanism of ALV-J. Using immunohistochemistry method of strep avidin-biotin complex (SABC),  many organs of illed egg-type chickens, involved liver, kidney, ventriculus glandularis, tumor, heart, pancreas, bone marrow, spleen, oviduct, lung, duodenum, thymus and bursa of fabricius were studied. And large numbers of mutant p53 protein were expressed in liver, kidney, ventriculus glandularis, tumor, oviduct. Moderate expression were detected in heart, pancreas, bone marrow, spleen, lung, duodenum, thymus and bursa of fabricius. The result suggested that expression of tumor suppressor gene p53 was concerned with occurrence and development of avian leukosis subgroup J.
Key wordsKey words: p53 tumor suppressor gene      avian leukosis subgroup J      egg-type chicken     
Received: 01 January 1900     
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Xu Binrui
Dong Weixing
He Zhaoqing
Yu Chunming
Li Ning
Feng Xiaoyu
L.F. Lee
Maoxiang Li
Cite this article:   
Xu Binrui,Dong Weixing,He Zhaoqing, et al. Expression of Mutant Tumor Suppressor Gene p53 in Egg-type Chicken
 Infected with Avian Leukosis Viruse Subgroup J
[J]. , 2003, 11(3): 276-279.
URL:  
http://journal05.magtech.org.cn/Jwk_ny/EN/      OR     http://journal05.magtech.org.cn/Jwk_ny/EN/Y2003/V11/I3/276
Copyright © Editorial Board of 农业生物技术学报
Supported by:Beijing Magtech