Abstract：Intestinal epithelial cells of tilapias, Oreochromis nilotica, were isolated and cultivated by primary culture of cells as the cells model to research the effect of Photosynthetic Bacteria (PSB0201) treated widely with the probiotic on the epithelial morphologic characters, viability, livability, permeability, cytosolic free calcium and membranous phospholipase A2 (PLA2) activity of tilapias. However, there was no significance （P > 0.01）comparing with the control although there was little effect of definited concentration PSB0201 on the intestine epithelial morphology and biochemical indexes. The result showed no harm on the epithelial cells of tilapia intestine during definite time and provided new idea and partial academic elements to reappraise the safety of PSB0201 treated as probiotic and apply in agriculture including aquaculturet.
