猪<em>CD163</em>基因编辑对PRRSV抗性及其他生理功能影响的分析

doi:10.3969/j.issn.1674-7968.2026.08.016

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Abstract Cluster of differentiation 163(CD163) protein is a critical receptor for the infection of Porcine reproductive and respiratory syndrome virus(PRRSV). In recent years, gene-editing technology has been utilized to breed PRRSV-resistant pigs. This review systematically examines the structure and physiological functions of the CD163 protein, summarizes domestic and international research cases in which PRRSV-resistant pigs have been successfully developed through various strategies(including complete deletion, partial deletion, replacement of the cysteine-rich scavenger receptor 5(SRCR5) domain, and single-base editing), and focuses on evaluating the impact of these genetic modifications on other key physiological functions of CD163, such as clearance of hemoglobin-haptoglobin complexes, promotion of erythrocyte development, and immune regulation, in order to provide scientific evidence and references for the safety of commercialized gene-edited disease-resistant animals. Substantial experimental evidence reveals that CD163-edited pigs exhibit complete resistance to PRRSV infection while retaining all normal physiological functions, including the clearance of free hemoglobin in plasma, the promotion of erythroblast development, and its function as a receptor for the TNF-like weak inducer of apoptosis(TWEAK). These findings provide crucial safety assurances for the commercial application of PRRSV-resistant gene-edited swine.

Key words： Gene editing CD163 gene function Porcine reproductive and respiratory syndrome virus(PRRSV)

Received: 10 October 2025

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Corresponding Authors: ^*liuxiayi@bjsngf.com.cn

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	LIU Xia-Yi
	TANG Bo
	LI Ning

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LIU Xia-Yi,TANG Bo,LI Ning. Analysis of the Impact of Porcine(Sus scrofa) CD163 Gene Editing on PRRSV Resistance and Other Physiological Functions[J]. 农业生物技术学报, 2026, 34(8): 1792-1802.

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https://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2026.08.016 OR https://journal05.magtech.org.cn/Jwk_ny/EN/Y2026/V34/I8/1792

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