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Abstract To study the mechanism of Changes of the ability of testosterone synthesis in different periods , kunbai mouse of different peroids wereused as experimental animals . the ability of testosterone synthesis was analyzed by RT-PCR and Western Blot.The results were as followed: (1) In all peroids, the expression of P450scc ,3β-HSD，StAR mRNA and protein had no significant change.(2)The expression of P450c17 mRNA had no significant change in 10d,60d,120d.however, The expression of P450c17 mRNA decreased significantly in 180d.(3) From 30d to 270d, the activity of ERK hadno significantchange. These results inferred that activity of ERK had no indirect. relationwith the decrease of P450c17 mRNA and the level of testosterone
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Received: 18 July 2006
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