Research Progress on the Regulation of Gametogenesis by circRNA in Livestock
YANG Meng-Hao, ZHANG Qi-Ming, QIN Xue, PANG Wei-Jun*
College of Animal Science and Technology, Northwest A & F University/Shaanxi Provincial Key Laboratory of Animal Genetics, Breeding and Reproduction, Yangling 712100, China
Abstract Gametogenesis is the process by which primordial germ cells differentiate into sperm or eggs through mitosis and meiosis, and these physiological activities are precisely regulated by stage-specific genes. CircRNA has a special closed loop structure, which is more stable than linear RNA, and plays important biological functions by regulating gene transcription, acting as a miRNA sponge, and participating in protein translation. Current studies have shown that circRNA is dynamically expressed during gamete occurrence in livestock and is an important new regulator of gamete occurrence. In this paper, the formation and biological functions of circRNA and the role and mechanism of regulating gametogenesis in domestic animals were reviewed, and the research direction of circRNA in gametogenesis was prospected. This review provides scientific basis for further exploring the potential mechanism of circRNA regulating gametogenesis in livestock.
YANG Meng-Hao,ZHANG Qi-Ming,QIN Xue, et al. Research Progress on the Regulation of Gametogenesis by circRNA in Livestock[J]. 农业生物技术学报, 2023, 31(11): 2401-2410.
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