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| Molecular Regulation Mechanism of Proliferation and Apoptosis in Bovine (Bos taurus) Mammary Epithelial Cells |
| REN Qian-Qian1,2, LUORENG Zhuo-Ma1,2, WANG Xing-Ping1,2,*, YANG Jian1,2, WEI Da-Wei1,2, MA Yun1,2 |
1 School of Agriculture, Ningxia University, Yinchuan 750021, China;
2 Key Laboratory of Ruminant Molecular Cell Breeding, Ningxia Hui Autonomous Region, Yinchuan 750021, China |
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Abstract Bovine mammary epithelial cells (bMECs) are the main cell type of mammary gland, they not only play the role of lactation, but also regulate the innate immune response of mammary gland. The proliferation and apoptosis of bMECs are regulated by enzymes, hormones, cytokines and other molecules, it is a cellular metabolic process of breast tissue in a specific physiological environment and affects the development and function of breast. In order to explore the function of mammary gland in dairy cows(Bos taurus), a lot of studies on the proliferation and apoptosis of bMECs have been carried out in recent years, and excellent results have been achieved. This paper mainly introduces the signaling pathways related to the cell proliferation and apoptosis, and focuses on the latest research progress of the regulation mechanism of proliferation and apoptosis by coding and non-coding genes (miRNA, lncRNA and circRNA) in bMECs, so as to provide reference for the further research of molecular breeding of high-yield and anti-mastitis dairy cows.
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Received: 12 May 2021
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Corresponding Authors:
*wxp@nxu.edu.cn
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