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| Research Progress in Effect of Branch-chain Amino Acids on Mammalian Protein Turnover and Its Mechanism |
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Abstract Abstract As an important signaling molecular, branch chain amino acids (BCAA) participate the synthesis and catabolism of protein of amino acids, and regulate food intake et al. in animal body. These processes include two conservative signaling pathway, one is the mammals target of rapamycin (mTOR) which sense of amino acid abundance, and another is the general amino acid control non-derepressible 2 (GCN2) which sense the absence of one or more amino acids by virtue of direct binding to uncharged tRNAs. This review mainly focused on the effect of BCAA on mTOR and GCN2 signaling pathway to further elucidate how BCAAs are involved in protein synthesis and catabolism. This review provides a reference for the study of protein turnover regulation in mammalian and gives a theoretical basis for BCAA application in feed additives.
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Received: 30 September 2017
Published: 21 May 2018
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